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Relation of cardiac function to insulin resistance as evaluated by hyperinsulinemic‐euglycemic clamp analysis in individuals with type 2 diabetes
- Source :
- Journal of Diabetes Investigation, Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2197-2202 (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Aims Whereas homeostasis model assessment of insulin resistance (HOMA‐IR), an easily measured but limited index of insulin resistance, has been shown to correlate with impairment of cardiac function in individuals without diabetes, the pathological relevance of insulin resistance to the development of cardiac dysfunction in individuals with type 2 diabetes has remained unclear. Here we investigated the relation between left ventricular (LV) function as assessed by echocardiography and insulin resistance as evaluated by hyperinsulinemic‐euglycemic clamp analysis, the gold standard for measurement of this parameter, in individuals with type 2 diabetes. Methods This retrospective study included 34 individuals with type 2 diabetes who underwent both hyperinsulinemic‐euglycemic clamp analysis and echocardiography. Both the insulin sensitivity index (ISI) as determined by glucose clamp analysis as well as HOMA‐IR were determined as measures of insulin resistance. The ratio of the peak early‐ to late‐diastolic mitral inflow velocities (E/A) and the LV ejection fraction (LVEF) were determined as measures of diastolic and systolic function, respectively. Results The ISI was significantly correlated with both the E/A ratio and LVEF (correlation coefficients of 0.480 and 0.360, respectively), whereas HOMA‐IR was not correlated with either cardiac parameter. Multivariate analysis revealed that ISI was an independent predictor for both a high log [E/A] (P = 0.031) and a high LVEF (P = 0.045). Conclusions Insulin resistance as evaluated by hyperinsulinemic‐euglycemic clamp analysis may be causally related to LV diastolic and systolic dysfunction in individuals with type 2 diabetes.<br />Our study suggested that insulin resistance as evaluated by glucose clamp analysis is associated with LV diastolic and systolic dysfunction in individuals with type 2 diabetes.
- Subjects :
- Adult
Blood Glucose
Male
Cardiac function curve
medicine.medical_specialty
Diabetic Cardiomyopathies
Endocrinology, Diabetes and Metabolism
Diastole
Type 2 diabetes
Diseases of the endocrine glands. Clinical endocrinology
Ventricular Function, Left
Ventricular Dysfunction, Left
Insulin resistance
insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Insulin
glucose clamp
Aged
Retrospective Studies
Ejection fraction
business.industry
Stroke Volume
Retrospective cohort study
Articles
General Medicine
Middle Aged
RC648-665
medicine.disease
Clinical Science and Care
Cross-Sectional Studies
Clamp
Diabetes Mellitus, Type 2
Echocardiography
Multivariate Analysis
Glucose Clamp Technique
Cardiology
Original Article
Female
business
left ventricular cardiac dysfunction
Subjects
Details
- ISSN :
- 20401124 and 20401116
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....3d375246bbe28567ca74f79cad153ffc