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Lack of association of apoE ε4 allele with insulin resistance
- Source :
- Acta Diabetologica. 49:25-32
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- ApoE is a polymorphic protein involved in the metabolism of plasma lipoproteins; the e4 allele was shown to be associated with coronary and aortic atherosclerosis in age-dependent fashion mediated by unknown mechanisms. This study was undertaken to assess whether the apoE isoforms in humans were associated with normal glucose tolerance and with metabolic and inflammatory risk factors of CVD. ApoE genotype was assessed in 365 individuals. Of those, 309 were studied in the postabsorptive conditions and 142 of them also underwent a 3h-OGTT; 56 additional subjects were studied by means of the insulin clamp in combination with [6,6-2H2] glucose infusion. ApoE genotype frequencies were similar to those previously reported and were not influenced by age and BMI. Fasting plasma glucose, insulin, FFA, the lipid profile, surrogate markers (HOMA-IR, OGTT-derived index) as well as the clamp-derived parameters or insulin sensitivity and insulin secretion were not different by apoE genotypes. Serum adipokines concentrations (leptin, adiponectin, resistin) and markers of inflammation (serum fasting hsCRP and MCP1/CCL2) were also not different by apoE genotypes. In the subgroup of young e4 carriers which underwent the clamp procedure, a higher fasting endogenous glucose production was detected. ApoE genotype was not associated with insulin resistance or altered insulin secretion, and no abnormalities in the typical circulating endocrine, metabolic, and inflammatory features of the insulin resistance syndrome were detected. © Springer-Verlag 2011
- Subjects :
- Adult
Male
Apolipoprotein E
medicine.medical_specialty
Genotype
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Adipokine
Oral glucose tolerance test
Biology
Low-grade inflammation
Young Adult
Apolipoproteins E
Endocrinology
Insulin resistance
Diabetes mellitus
Internal medicine
Insulin Secretion
HOMA
Internal Medicine
medicine
Humans
Insulin
Insulin clamp
MED/13 - ENDOCRINOLOGIA
Alleles
Genetic Association Studies
Aged
Adiponectin
General Medicine
Glucose Tolerance Test
Middle Aged
medicine.disease
Metabolic syndrome
Glucose Clamp Technique
Female
lipids (amino acids, peptides, and proteins)
Resistin
Insulin Resistance
ApoE
Subjects
Details
- ISSN :
- 14325233 and 09405429
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....3d2f8345cd9b7217d3006f5f6eeafe65