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The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age
- Source :
- The American Journal of Tropical Medicine and Hygiene. 96:243-248
- Publication Year :
- 2016
- Publisher :
- American Society of Tropical Medicine and Hygiene, 2016.
-
Abstract
- Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case–control study design, residents in a rural village (Atahualpa) aged ≥ 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder. The prevalence of hippocampal atrophy was compared between cases and control subjects by the use of the McNemar's test for correlated proportions. Seventy-five individuals with calcified NCC and their matched control subjects were included in the analysis. Hippocampal atrophy was noted in 26 (34.7%) cases and nine (12%) control subjects (odds ratio: 4.4; 95% confidence interval: 1.6–14.9, P < 0.0021). Stratification of pairs according to tertiles of age revealed an age-related trend in this association, which became significant only in those aged ≥ 68 years (P = 0.027). Only five cases and one control had recurrent seizures (P = 0.221); three of these five cases had hippocampal atrophy, and the single control subject had normal hippocampi. This study confirms an association between NCC and hippocampal atrophy, and shows that this association is stronger in older age groups. This suggests that NCC-related hippocampal atrophy takes a long time to develop.
- Subjects :
- Adult
Male
Rural Population
0301 basic medicine
Neurocysticercosis/parasitology/pathology
Aging
medicine.medical_specialty
Pathology
030106 microbiology
Neurocysticercosis
Hippocampal formation
Hippocampus
03 medical and health sciences
0302 clinical medicine
McNemar's test
Risk Factors
Virology
Internal medicine
Odds Ratio
medicine
Humans
Atrophy/parasitology/pathology
Association (psychology)
Aged
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Articles
Odds ratio
Middle Aged
Confidence interval
Hippocampal atrophy
Infectious Diseases
Case-Control Studies
Hippocampus/parasitology/pathology
Female
Parasitology
Atrophy
business
purl.org/pe-repo/ocde/ford#3.03.06 [https]
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14761645 and 00029637
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....3d2c2dc06a7e172e580a8388234374ba