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New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP
- Source :
- Discover. Oncology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore, there is a current urgent need to define novel predictive genetic predictors that may be useful for stratifying patients with distinct prognostic outcomes. Here, we looked for novel molecular signatures for triple negative breast cancers (TNBCs). By a bioinformatic approach, we identified a panel of genes, whose expression was positively correlated with disease-free survival in TNBC patients, namely IL18R1, CD53, TRIM, Jaw1, LTB, and PTPRCAP, showing specific immune expression profiles linked to survival prediction; most of these genes are indeed expressed in immune cells and are required for productive lymphocyte activation. According to our hypothesis, these genes were not, or poorly, expressed in different TNBC cell lines, derived from either primary breast tumours or metastatic pleural effusions. This conclusion was further supported in vivo, as immuno-histochemical analysis on biopsies of TNBC invasive ductal carcinomas highlighted differential expression of these six genes in cancer cells, as well as in intra- and peri-tumoral infiltrating lymphocytes. Our data open to the possibility that inter-tumour heterogeneity of immune markers might have predictive value; further investigations are recommended in order to establish the real power of cancer-related immune profiles as prognostic factors. Supplementary Information The online version contains supplementary material available at 10.1007/s12672-021-00401-0.
- Subjects :
- 0301 basic medicine
Cancer Research
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Cancer immunity
Jaw1
Prognostic markers
03 medical and health sciences
TRIM
0302 clinical medicine
Endocrinology
Immune system
Breast cancer
cancer immunity
cd53
il18r1
jaw1
ltb
precision oncology
prognostic markers
ptprcap
trim
triple negative breast cancer
Surgical oncology
medicine
Triple negative breast cancer
Settore BIO/10
IL18R1
Triple-negative breast cancer
Endocrine and Autonomic Systems
Genetic heterogeneity
business.industry
Research
Precision oncology
PTPRCAP
medicine.disease
Molecular medicine
Radiation therapy
030104 developmental biology
Oncology
LTB
030220 oncology & carcinogenesis
Cancer cell
Cancer research
CD53
business
Subjects
Details
- ISSN :
- 27306011
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Discover Oncology
- Accession number :
- edsair.doi.dedup.....3d1c633aefa046c4beda026606354450