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Pretreatment serum human chorionic gonadotropin cutoff value for medical treatment success with single-dose and multi-dose regimen of methotrexate in tubal ectopic pregnancy
- Source :
- Obstetrics & Gynecology Science
- Publication Year :
- 2017
- Publisher :
- Korean Society of Obstetrics and Gynecology, 2017.
-
Abstract
- Objective To investigate individual pretreatment serum human chorionic gonadotropin (hCG) cutoff value for medical treatment success with single-dose and multi-dose regimen of methotrexate in tubal ectopic pregnancy. Methods Eighty-five women who received methotrexate for the treatment of tubal ectopic pregnancy during 2003 to 2015 were selected. Fifty-three women received a single-dose regimen and 32 women received a multi-dose regimen. Medical treatment failure was defined as necessity of surgical treatment. The medical treatment success rate was estimated in both regimens and the pretreatment serum hCG titer to predict the success was assessed by receiver operating characteristics curve analysis. Results Pretreatment clinical and laboratory parameters were similar between group of single-dose regimen and multi-dose regimen. Treatment success rate was 64.2% in the single-dose regimen group and 71.9% in the multi-dose regimen group (P>0.05). Pretreatment serum hCG titer was an independent prognostic factor for treatment success in each regimen. Serum hCG cutoff value to predict the treatment success was 3,026 IU/L in single-dose regimen group and 3,711 IU/L in multi-dose regimen group. Conclusion We recommend use of single-dose regimen when pretreatment serum hCG
- Subjects :
- medicine.medical_specialty
Pregnancy, tubal
Urology
Human chorionic gonadotropin
03 medical and health sciences
0302 clinical medicine
medicine
Cutoff
030212 general & internal medicine
Gynecology
Pregnancy
030219 obstetrics & reproductive medicine
Medical treatment
business.industry
Tubal ectopic pregnancy
Obstetrics and Gynecology
medicine.disease
Chorionic gonadotropin
Titer
Regimen
Methotrexate
Original Article
General Gynecology
business
medicine.drug
Subjects
Details
- ISSN :
- 22878580 and 22878572
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Obstetrics & Gynecology Science
- Accession number :
- edsair.doi.dedup.....3d0f3b1cf01f5ab7bf7c3b7532886df7