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Preeclampsia and academic performance in children: A nationwide study from Iceland
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 11, p e0207884 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- Publisher's version (útgefin grein)<br />Background Hypertensive disorders complicate up to 10% of pregnancies. Evidence suggests a potential association between maternal hypertensive disorders during pregnancy, particularly preeclampsia, and adverse neurodevelopment in the offspring, but existing studies are subject to limitations. We aimed to assess whether in-utero exposure to preeclampsia/eclampsia negatively impacts academic performance at ages 9, 12 and 15 years. Methods Using individually linked, nationwide data from the Icelandic registries we followed all children born in 1989–2004 (N = 68,580), from birth until the end of 2014, thereof 63,014 (91.9%) took at least one standardized test. Using a stepwise, mixed-effects approach, we modelled the hypothesized relationship while adjusting for maternal, perinatal and childhood variables of interest. We compared test scores, measured on a normalized scale ranging from 0–60 with a mean of 30 and a standard deviation of 10, in the 4th, 7th, and 10th grades, between children exposed to preeclampsia or eclampsia in-utero versus children from normotensive pregnancies in the population. Results Children exposed to preeclampsia/eclampsia scored lower than those unexposed in mathematics across all grade levels, corresponding to a difference of 0.44 points (95% CI: 0.00, 0.89), 0.59 points (95% CI: 0.13, 1.06) and 0.59 points (95% CI: 0.08, 1.10), respectively. No differences were observed in the language arts. Conclusions Our findings suggest a minimal effect of maternal preeclampsia/eclampsia on children’s academic performance at ages 9, 12 and 15 years. The differences observed in mathematic scores between exposed and unexposed children were minimal, less than one tenth of a standard deviation per measurement occasion.<br />HZ received financial support for this study from the Icelandic Centre for Research, START – Reintegration fellowship, under Award Number 130814-051, http://www.rannis.is. BTB was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (Bethesda, Maryland, United States) under Award Number K08HD075831. Dr. Helga Zoega was supported by a Scientia Fellowship awarded by the University of New South Wales. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Subjects :
- Male
Multivariate analysis
Maternal Health
Iceland
lcsh:Medicine
Social Sciences
Blood Pressure
Börn
Academic Skills
Vascular Medicine
Pediatrics
Geographical Locations
Cohort Studies
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Færni
Academic Performance
Medicine and Health Sciences
Psychology
Hypertensive disorders in pregnancy
Meðganga
lcsh:Science
Child
reproductive and urinary physiology
Language
education.field_of_study
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Obstetrics and Gynecology
Europe
Háþrýstingur
Neurology
Hypertension
Female
Cohort study
Research Article
Adult
medicine.medical_specialty
Menntun
Adolescent
Offspring
Population
Academic skills
Standardized test
Neuropsychiatric Disorders
Preeclampsia
03 medical and health sciences
Developmental Neuroscience
Hypertensive Disorders in Pregnancy
030225 pediatrics
Mental Health and Psychiatry
medicine
ADHD
Humans
education
Eclampsia
business.industry
lcsh:R
Cognitive Psychology
Biology and Life Sciences
medicine.disease
Pregnancy Complications
Neurodevelopmental Disorders
People and Places
Multivariate Analysis
Birth
Women's Health
Cognitive Science
lcsh:Q
Adhd
business
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3d08ab328466c43c8ab1387b46c1a3d7