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Inflammatory pain by carrageenan recruits low-frequency local field potential changes in the anterior cingulate cortex
- Source :
- Neuroscience letters. 632
- Publication Year :
- 2016
-
Abstract
- The anterior cingulate cortex (ACC) has been extensively cited as a key area for processing pain affect. While local field potential (LFP) studies in other fields have yielded a great deal of information about neural oscillations, there is a poverty in the pain literature about the neural LFP profile related to pain, particularly in freely moving animals. In this study, we revealed the LFP profile in the ACC in freely moving rats during carrageenan inflammation. Mechanical allodynia was recorded before and after unilateral injection of carrageenan/saline in the left hindpaw. LFP activity in the ACC was recorded at baseline, after injection, and after injection with mechanical stimulation to the paw using a von Frey filament. This study uniquely reveals that carrageenan injection significantly recruited ACC LFP activity in delta, theta, and alpha bands (0-13Hz). Application of von Frey mechanical stimulation to the carrageenan-injected paw resulted in a significant increase in delta, theta, and alpha bands over and above what was recruited by carrageenan alone and further expanded the LFP range to additionally include beta activity (13-30Hz). Taken together, these data reveal significant changes in the lowest-frequency activities in the LFP range during painful inflammation, which merit attention. LFP is a powerful window to reveal wide-range, integrated synaptic processing by low-frequency cellular events during behavior. Information about LFP during pain broadens the scope of our understanding of pain mechanisms, our greatest resource for designing management approaches.
- Subjects :
- 0301 basic medicine
Male
Pain Threshold
genetic structures
Alpha (ethology)
Action Potentials
Pain
Stimulation
Local field potential
Carrageenan
Gyrus Cinguli
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Threshold of pain
medicine
Animals
Evoked potential
Anterior cingulate cortex
Inflammation
General Neuroscience
Rats
030104 developmental biology
medicine.anatomical_structure
nervous system
chemistry
Von frey
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 632
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....3d07c96ccd5669df785facce5dd78c11