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Fast and effective mitochondrial delivery of omega-Rhodamine-B-polysulfobetaine-PEG copolymers
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018), Scientific Reports
- Publication Year :
- 2018
-
Abstract
- Mitochondrial targeting and entry, two crucial steps in fighting severe diseases resulting from mitochondria dysfunction, pose important challenges in current nanomedicine. Cell-penetrating peptides or targeting groups, such as Rhodamine-B (Rho), are known to localize in mitochondria, but little is known on how to enhance their effectiveness through structural properties of polymeric carriers. To address this issue, we prepared 8 copolymers of 3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate and poly(ethyleneglycol) methacrylate, p(DMAPS-ran-PEGMA) (molecular weight, 18.0 M n M n
- Subjects :
- 0301 basic medicine
Polymers
116 Chemical sciences
Chemistry Techniques, Synthetic
02 engineering and technology
Mitochondrion
Polyethylene Glycols
Cell membrane
chemistry.chemical_compound
Fluorescence microscope
Rhodamine B
DRUG-DELIVERY
Internalization
media_common
ARGININE-RICH PEPTIDES
Multidisciplinary
Molecular Structure
Chemistry
MITO-PORTER
CHOLESTEROL
021001 nanoscience & nanotechnology
Mitochondria
3. Good health
TRANSLOCATION
medicine.anatomical_structure
Drug delivery
Methacrylates
Medicine
0210 nano-technology
Science
media_common.quotation_subject
CELLULAR UPTAKE
Endocytosis
Article
03 medical and health sciences
PEG ratio
medicine
Humans
Rhodamines
Biological Transport
IN-VITRO
Quaternary Ammonium Compounds
030104 developmental biology
LIPOSOME-BASED CARRIER
CELLS
Biophysics
MEMBRANE
HeLa Cells
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018), Scientific Reports
- Accession number :
- edsair.doi.dedup.....3cfc2f9f4f007f1e6686e91105e5e093