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Attenuation of d-amphetamine-induced disruption of conditional discrimination performance by ?-flupenthixol
- Source :
- Psychopharmacology. 177:296-306
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Previous evidence suggests that manipulation of forebrain dopamine (DA) systems may impair the use of conditional information to inform goal-directed performance, and this may be related to impairments in the ability to use task-setting cues in schizophrenia.To investigate, using the indirect DA agonist d-amphetamine and the D1/D2 receptor antagonist alpha-flupenthixol, the influence of DAergic manipulation on discrimination performance that requires the use of conditional information to inform goal-directed performance.Both instrumental and Pavlovian conditional discriminations were employed in which rats learned to respond appropriately according to the presence of auditory conditional stimuli, and results from these experiments were contrasted with a control Pavlovian-instrumental transfer task.Experiment 1 showed a disruption of instrumental conditional discrimination performance by d-amphetamine at 1.5 mg/kg and attenuation of correct responding following 1.0 mg/kg. Disruption with both doses was observed in experiment 2 using a conditional discrimination based on Pavlovian, conditioned responding. Results from a control Pavlovian-instrumental transfer task (experiment 3) revealed that d-amphetamine (0.5, 1.0 and 1.5 mg/kg) did not have any detrimental effect on subjects' basic sensory, motor or motivational processes. Experiment 4 showed that d-amphetamine disruption of instrumental conditional discrimination was attenuated by pre-treatment with the D1/D2 receptor antagonist alpha-flupenthixol.These results demonstrate that tasks dependent on conditional relationships are highly sensitive to manipulation of DAergic systems.
- Subjects :
- Male
Agonist
Psychosis
Dextroamphetamine
Signal Detection, Psychological
Psychopharmacology
medicine.drug_class
Conditioning, Classical
Sensory system
Context (language use)
Extinction, Psychological
Developmental psychology
Discrimination Learning
Avoidance Learning
Reaction Time
medicine
Animals
Amphetamine
Pharmacology
Behavior, Animal
Antagonist
medicine.disease
Rats
Flupentixol
Flupenthixol
Inhibition, Psychological
Dopamine receptor
Conditioning, Operant
Psychology
Neuroscience
Injections, Intraperitoneal
Psychomotor Performance
medicine.drug
Subjects
Details
- ISSN :
- 14322072 and 00333158
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....3ce24723ff3b1f272c81767ecd1d1c7b