Back to Search
Start Over
Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages
- Source :
- Alzheimer'sdementia : the journal of the Alzheimer's Association. 14(5)
- Publication Year :
- 2017
-
Abstract
- Introduction Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated. Methods We conducted genome-wide association studies for AD-related endophenotypes including hippocampal volume, logical memory scores, and cerebrospinal fluid Aβ 42 and total/phosphorylated tau in cognitively normal (CN), mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative study. Results In CN subjects, study-wide significant ( P −9 ) loci were identified for total tau near SRRM4 and C14orf79 and for hippocampal volume near MTUS1 . In mild cognitive impairment subjects, study-wide significant association was found with single nucleotide polymorphisms (SNPs) near ZNF804B for logical memory test of delayed recall scores. We found consistent expression patterns of C14orf40 and MTUS1 in carriers with risk alleles of expression SNPs and in brains of AD patients, compared with in the noncarriers and in brains of controls. Discussion Our findings for AD-related brain changes before AD provide insight about early AD-related biological processes.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Epidemiology
Endophenotypes
Genome-wide association study
Single-nucleotide polymorphism
Nerve Tissue Proteins
tau Proteins
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Neuroimaging
Alzheimer Disease
Internal medicine
mental disorders
medicine
Dementia
Humans
Cognitive Dysfunction
Phosphorylation
Genetic association
Amyloid beta-Peptides
business.industry
Health Policy
Cognition
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
030104 developmental biology
Early Diagnosis
Endophenotype
Biomarker (medicine)
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15525279
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer'sdementia : the journal of the Alzheimer's Association
- Accession number :
- edsair.doi.dedup.....3cda0e4cb10710c5f5d9546ccf964a4c