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Data on the involvement of endothelin-1 (ET-1) in the dysregulation of retinal veins
- Source :
- Data in Brief, Vol 21, Iss, Pp 59-62 (2018), Data in Brief
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Retinal vein occlusion (RVO) is a common vascular disease of the retina; however, the pathogenesis of RVO is still unclear. Branch RVO (BRVO) commonly occurs at the arteriovenous crossing and it was formerly believed that the diseased artery mechanically compresses the vein. However, it has been reported that the retinal vein runs deep beneath the artery at the arteriovenous crossing in eyes with an arterial overcrossing, and the venous lumen often appears to be preserved, even at the arteriovenous crossing, as shown by optical coherence tomography. Paques et al. [1] found venous nicking without arteriovenous contact using adaptive optics imaging. Thus, we investigated the potential role of a dysregulation of the retinal vein. While the pathogenesis of retinal vein occlusion (RVO) is still unclear, systemic hypertension and increased level of endothelin-1 (ET-1) are known risk factors (Flammer and Konieczka, 2015) [2]. We focused on the behavior of retinal veins in spontaneous hypertensive rats (SHR). Then, one of the retinal veins became exceptionally constricted and was nearly occluded (Fig. 1), and the chorioretinal blood flow significantly decreased in the retinas of SHRs following the intravenous injection of ET-1. In addition, immunoreactivity to ET-A receptor was higher in SHR retinas than in control (WKY; Wistar Kyoto rat) retinas (Fig. 2). The protein levels of ET-A receptor and HIF-1 were also significantly higher in SHR retinas than in WKY retinas (Fig. 3). We observed vasoactivity of retinal veins; a retinal venous constriction (Kida et al., 2018) [3]. This supports the hypothesis that ET-1 can constrict retinal veins, thus increasing retinal venous pressure, and that ET-1 may even contribute to the pathogenesis of RVO.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Retinal Vein
lcsh:Computer applications to medicine. Medical informatics
Constriction
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Biochemistry, Genetics and Molecular Biology
Ophthalmology
medicine
lcsh:Science (General)
Vein
Retina
Multidisciplinary
business.industry
Vascular disease
Retinal
medicine.disease
Endothelin 1
030104 developmental biology
medicine.anatomical_structure
chemistry
cardiovascular system
030221 ophthalmology & optometry
lcsh:R858-859.7
business
lcsh:Q1-390
Artery
Subjects
Details
- ISSN :
- 23523409
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....3cd7011fb63115070678bfbd7c0d4217