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Enhancement of the Effects of Anti-Staphylococcal Antibiotics by Aminoglycosides
- Source :
- Antimicrobial Agents and Chemotherapy. 6:802-806
- Publication Year :
- 1974
- Publisher :
- American Society for Microbiology, 1974.
-
Abstract
- The in vitro activity of seven anti-staphylococcal antibiotics alone and in combination with four aminoglycoside antibiotics against 35 clinical isolates of Staphylococcus aureus from blood cultures of patients with endocarditis or septicemia was studied. The combination of nafcillin-gentamicin or nafcillin-tobramycin when compared with nafcillin alone killed significantly more S. aureus at 6 h for 33 of 35 isolates. A significant decrease in viable colony-forming units at 24 and 48 h was demonstrated for a smaller number of isolates. Using the agar dilution antibiotic susceptibility test, significant enhancement of activity was demonstrated against almost all isolates when cephalothin, cefazolin, or clindamycin was combined with gentamicin, tobramycin, or kanamycin. The combination of nafcillin or vancomycin with gentamicin, tobramycin, or kanamycin also showed enhanced activity against the majority of isolates. Oxacillin or methicillin when combined with the aminoglycosides showed enhancement of activity against the least number of isolates. Streptomycin was the least effective of the four aminoglycoside antibiotics studied.
- Subjects :
- Staphylococcus
Microbial Sensitivity Tests
medicine.disease_cause
Agar dilution
Microbiology
Nafcillin
Methicillin
Kanamycin
polycyclic compounds
medicine
Tobramycin
Pharmacology (medical)
Oxacillin
Pharmacology
business.industry
Clindamycin
Aminoglycoside
Drug Synergism
Articles
biochemical phenomena, metabolism, and nutrition
Anti-Bacterial Agents
Cephalosporins
Aminoglycosides
Infectious Diseases
Staphylococcus aureus
Streptomycin
Vancomycin
Gentamicin
Gentamicins
business
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....3cd338b6dc6e95ae0ec57caba6d443ec