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Modeling Relapsing Malaria: Emerging Technologies to Study Parasite-Host Interactions in the Liver
- Source :
- Frontiers in Cellular and Infection Microbiology, Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Recent studies of liver stage malaria parasite-host interactions have provided exciting new insights on the cross-talk between parasite and its mammalian (predominantly rodent) host. We review the latest state of the art and and zoom in on new technologies that will provide the tools necessary to investigate host-parasite interactions of relapsing parasites. Interactions between hypnozoites and hepatocytes are particularly interesting because the parasite can remain in a quiescent state for prolonged periods of time and triggers for reactivation have not been irrefutably identified. If we learn more about the cross-talk between hypnozoite and host we may be able to identify factors that encourage waking up these dormant parasite reservoirs and help to achieve the total eradication of malaria.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Emerging technologies
Mini Review
030231 tropical medicine
Immunology
lcsh:QR1-502
malaria
cynomolgi
Biology
Microbiology
Plasmodium
lcsh:Microbiology
Host-Parasite Interactions
03 medical and health sciences
0302 clinical medicine
Cellular and Infection Microbiology
medicine
Parasite hosting
Animals
Liver stage
parasite-host interaction
relapse
Quiescent state
biology.organism_classification
medicine.disease
030104 developmental biology
Infectious Diseases
Liver
plasmodium
Hepatocytes
Parasite-Host Interactions
Malaria
hypnozoite
Plasmodium cynomolgi
Subjects
Details
- Language :
- English
- ISSN :
- 22352988
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular and Infection Microbiology
- Accession number :
- edsair.doi.dedup.....3cd2421aca624e5db995b6df702df7f1