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Aging features of the migratory locust at physiological and transcriptional levels
- Source :
- BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021), BMC Genomics
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Non-Drosophila insects provide diverse aging types and important complementary systems for studies of aging biology. However, little attention has been paid to the special roles of non-Drosophila insects in aging research. Here, the aging-related features of the migratory locust, Locusta migratoria, were determined at the physiological, cellular, and transcriptional levels. Results In physiological assessments, the flight performance and sperm state of locusts displayed clear aging-related decline in male adults. Transcriptional analyses demonstrated locusts have similar aging-related genes with model species. However, different from those of Drosophila and mammals, the organ-specific aging transcriptional features of locusts were characterized by intensive expression changes in flight muscle and fat body and little transcriptional changes in brain. The predominant transcriptional characteristics of flight muscle and fat body aging were changes in expression of mitochondrion-related genes and detoxification and phagocytosis genes, respectively. Cellular assessments revealed the incidence of mitochondrial abnormalities significantly increased in aged flight muscle, and apoptotic signals and nuclear abnormalities were enhanced in aged fat body but not in brain. In addition, some well-known aging genes and locust aging-related genes (i.e., IAP1, PGRP-SA, and LIPT1), whose roles in aging regulation were rarely reported, were demonstrated to affect lifespan, metabolism, and flight ability of locusts after RNAi. Conclusion This study revealed multi-level aging signatures of locust, thus laying a foundation for further investigation of aging mechanisms in this famous insect in the future.
- Subjects :
- Male
Aging
animal structures
lcsh:QH426-470
lcsh:Biotechnology
media_common.quotation_subject
Locusta migratoria
Insect
Proteomics
Transcriptome
03 medical and health sciences
RNA interference
0302 clinical medicine
Systematic assessments
lcsh:TP248.13-248.65
Genetics
Animals
Transcriptomics
Gene
030304 developmental biology
media_common
0303 health sciences
Organ specificity
biology
Migratory locust
biology.organism_classification
Non-Drosophila insect
Cell biology
lcsh:Genetics
DNA microarray
030217 neurology & neurosurgery
Locust
Research Article
Biotechnology
Subjects
Details
- ISSN :
- 14712164
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- BMC Genomics
- Accession number :
- edsair.doi.dedup.....3cd09ee3aba88ad4d665f89fd97ce823