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Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth
- Source :
- Reproduction. 154:67-77
- Publication Year :
- 2017
- Publisher :
- Bioscientifica, 2017.
-
Abstract
- Relaxin, a systemic and placental hormone, has potential roles in fetoplacental growth. Human placenta expresses two RLN genes, RLNH1 and RLNH2. Maternal obesity is common and is associated with abnormal fetal growth. Our aims were to relate systemic and cord blood RLNH2, placental RLNs and their receptor (RXFP1) with fetoplacental growth in context of maternal body mass index, and associations with insulin-like growth factor 2 (IGF2) and vascular endothelial growth factor A (VEGFA) in the same placentas. Systemic, cord blood and placental samples were collected prior to term labor, divided by prepregnancy body mass index: underweight/normal (N = 25) and overweight/obese (N = 44). Blood RLNH2 was measured by ELISA; placental RLNH2, RLNH1, RXFP1, IGF2 and VEGFA were measured by quantitative immunohistochemistry and mRNAs were measured by quantitative reverse transcription PCR. Birthweight increased with systemic RLNH2 only in underweight/normal women (P = 0.036). Syncytiotrophoblast RLNH2 was increased in overweight/obese patients (P = 0.017) and was associated with placental weight in all subjects (P = 0.038). RLNH1 had no associations with birthweight or placental weight, but was associated with increased trophoblast and endothelial IGF2 and VEGFA, due to female fetal sex. Thus, while systemic RLNH2 may be involved in birthweight regulation in underweight/normal women, placental RLNH2 in all subjects may be involved in placental weight. A strong association of trophoblast IGF2 with birthweight and placental weight in overweight/obese women suggests its importance. However, an association of only RLNH1 with placental IGF2 and VEGFA was dependent upon female fetal sex. These results suggest that both systemic and placental RLNs may be associated with fetoplacental growth.
- Subjects :
- Vascular Endothelial Growth Factor A
0301 basic medicine
Embryology
medicine.medical_specialty
Receptors, Peptide
Placenta
Gene Expression
Context (language use)
Overweight
Article
Body Mass Index
Receptors, G-Protein-Coupled
Fetal Development
03 medical and health sciences
Fetus
Sex Factors
0302 clinical medicine
Endocrinology
Syncytiotrophoblast
Insulin-Like Growth Factor II
Pregnancy
Internal medicine
medicine
Birth Weight
Humans
Insulin
Obesity
030219 obstetrics & reproductive medicine
business.industry
Proteins
Obstetrics and Gynecology
Trophoblast
Organ Size
Cell Biology
Fetal Blood
Immunohistochemistry
Pregnancy Complications
Vascular endothelial growth factor A
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
Cord blood
Female
Underweight
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 17417899 and 14701626
- Volume :
- 154
- Database :
- OpenAIRE
- Journal :
- Reproduction
- Accession number :
- edsair.doi.dedup.....3ccf083b127473fe6e277128cab217ae
- Full Text :
- https://doi.org/10.1530/rep-17-0039