Back to Search
Start Over
Risperidone medication errors in children: an analysis of French poison centres data
- Source :
- Clinical Toxicology. 57:362-367
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- To describe clinical consequences of risperidone medication errors in children of less than 13 years and to estimate a clinically relevant toxic dose.All cases of risperidone medication errors managed by French Poison Centres from 2001 to 2012 were analyzed. Inclusion criteria were a delay of at least 2 hours between ingestion and request to the FPC in asymptomatic children, an ingested dose above two-fold the maximal daily dose for children above 5 years or any symptomatic patient at the time of first contact.One hundred and sixty cases met our criteria. Median age was 8 years (range 0.9-12) and 28.1% were aged 5 years or less. Causes of the error were an incorrect dose in treated children (84.2%) or a dose given to a wrong child (15.8%). The median ingested dose was 0.1 mg/kg or 3.3-fold the maximum recommended dose. Overall, 59 children had no symptoms, 95 experienced minor symptoms and six moderate symptoms. Somnolence/sedation was the most common (73.3%). Of the 17 children who developed extrapyramidal disorders, all had minor or moderate symptoms and only five required a symptomatic treatment.Risperidone medication errors in children cause minimal effects. Somnolence and mild to moderate extrapyramidal reactions were the main features of toxicity, and significant cardiac or other neurological features were not observed. No case with severe toxicity was noted. At home surveillance can be proposed for children exposed to a dose ≤0.15 mg/kg.
- Subjects :
- Male
medicine.medical_specialty
Poison Control Centers
Sleepiness
Injury control
Accident prevention
Poison control
Toxicology
Risk Assessment
Suicide prevention
Occupational safety and health
03 medical and health sciences
0302 clinical medicine
Basal Ganglia Diseases
Injury prevention
medicine
Humans
Medication Errors
030212 general & internal medicine
Child
Retrospective Studies
Risperidone
Dose-Response Relationship, Drug
business.industry
Age Factors
Infant
Human factors and ergonomics
030208 emergency & critical care medicine
General Medicine
Prognosis
Child, Preschool
Emergency medicine
Female
France
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 15569519 and 15563650
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Clinical Toxicology
- Accession number :
- edsair.doi.dedup.....3cbd0a7d004b547885980cc3515d661c