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Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 180(5)
- Publication Year :
- 2008
-
Abstract
- Therapies that control largely T cell-dependent allograft rejection in humans also possess the undesirable effect of impairing T cell function, leaving transplant recipients susceptible to opportunistic viruses. Prime among these opportunists are the ubiquitous herpesviruses. To date, studies are lacking that address the effect of viruses that establish a true latent state on allograft tolerance or the effect of tolerance protocols on the immune control of latent viruses. By using a mixed chimerism-based tolerance-induction protocol, we found that mice undergoing latent infection with γHV68, a murine γ-herpesvirus closely related to human γ-herpesviruses such as EBV and Kaposi’s sarcoma-associated herpesvirus, significantly resist tolerance to allografts. Limiting the degree of virus reactivation or innate immune response did not reconstitute chimerism in latently infected mice. However, γHV68-infected mice showed increased frequency of CD8+ T cell alloreactivity and, interestingly, expansion of virus-induced, alloreactive, “effector/effector memory” TCR Vβ4+CD8+ T cells driven by the γHV68-M1 gene was associated with resistance to tolerance induction in studies using γHV68-M1 mutant virus. These results define the viral gene and immune cell types involved in latent infection-mediated resistance to allograft tolerance and underscore the influence of latent herpesviruses on allograft survival.
- Subjects :
- Rhadinovirus
viruses
T cell
Immunology
Biology
CD8-Positive T-Lymphocytes
Virus
Mice
Immune system
medicine
Immunology and Allergy
Cytotoxic T cell
Animals
Bone Marrow Transplantation
Mice, Inbred BALB C
Mice, Inbred C3H
Innate immune system
T-cell receptor
Graft Survival
Herpesviridae Infections
Skin Transplantation
Virology
Immunity, Innate
Virus Latency
Mice, Inbred C57BL
Tolerance induction
medicine.anatomical_structure
Radiation Chimera
Genes, T-Cell Receptor beta
Transplantation Tolerance
Immunologic Memory
CD8
Cell Division
Subjects
Details
- ISSN :
- 00221767
- Volume :
- 180
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.doi.dedup.....3cadaab3d6bdb37c0fceb6f1269a522d