Pathologic studies in man after prolonged ingestion of fluoride in drinking water I. Necropsy findings in a community with a water level of 2.5 ppm

The value of artificial fluoridation of drinking water in the prevention of den­ tal caries has been accepted generally. Furthermore, much evidence has been accumulated to indicate that 1 ppm is a safe level that permits beneficial effect and yet avoids possible toxic cumulative effect. This evidence in man is of clini­ cal, statistical and roentgenographic char­ acter.1"8 The present study was instituted to furnish information concerning possible pathologic effects in residents of an area with a high natural level of fluoride.