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Biology of phosphatidylserine (PS): basic physiology and implications in immunology, infectious disease, and cancer
- Source :
- Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-5 (2020), Cell Communication and Signaling : CCS
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restricted to the inner leaflet of the plasma membrane. However, during cellular activation and/or induction of cell death, PS is externalized on the outer surface via the activation of phospholipid scramblases. Externalized PS not only changes the biochemical and biophysical properties of the plasma membrane but also initiates a series of interactions between endogenous extracellular proteins as well as receptors on neighboring cells to stimulate engulfment (efferocytosis) that influence the surrounding immune milieu. In this thematic series published in Cell Communication and Signaling, we feature review articles that highlight recent work in the field of PS biology, including the biochemistry and physiological significance of PS externalization, therapeutic applications and efforts to target PS, as well as posit open questions that remain in the field.
- Subjects :
- Programmed cell death
Phospholipid scramblase
Cell
Phospholipid
lcsh:Medicine
Cell Communication
Phosphatidylserines
Biology
Communicable Diseases
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Neoplasms
Organelle
medicine
Animals
Humans
lcsh:QH573-671
Receptor
Efferocytosis
Molecular Biology
0303 health sciences
lcsh:Cytology
Cell Membrane
030302 biochemistry & molecular biology
lcsh:R
Cell Biology
Phosphatidylserine
Cell biology
Editorial
medicine.anatomical_structure
chemistry
Signal Transduction
Subjects
Details
- Language :
- English
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cell Communication and Signaling
- Accession number :
- edsair.doi.dedup.....3c9e78a4dc9b462592d12124c9b2becf