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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas

Authors :
Alessandro Spina
Annamaria Giordano
Mario Delia
Domenico Pastore
Vincenzo Liso
Francesco Gaudio
Clara De Risi
Paola Curci
Tommasina Perrone
Vincenzo Pavone
Giorgina Specchia
Source :
Advances in Hematology, Vol 2011 (2011), Advances in Hematology
Publication Year :
2011
Publisher :
Hindawi Publishing Corporation, 2011.

Abstract

Recurrences of Hodgkin's Lymphoma (HL) 5 years after the initial therapy are rare. The aim of this study is to report a single centre experience of the clinical characteristics, outcome, and toxicity of pts who experienced very late relapses, defined as relapses that occurred 5 or more years after the achievement of first complete remission. Of 532 consecutive pts with classical HL treated at our Institute from 1985 to 1999, 452 pts (85%) achieved a complete remission. Relapse occurred in 151 pts: 135 (29.8%) within 5 years and 16 over 5 years (3.5%, very late relapses). Very late relapses occurred after a median disease-free interval of 7 years (range: 5–18). Salvage treatment induced complete remission in 14 pts (87.5%). At a median of 4 years after therapy for very late relapse, 10 pts (63%) are still alive and free of disease and 6 (37%) died (1 from progressive HL, 1 from cardiac disease, 1 from thromboembolic disease, 1 from HCV reactivation, and 2 from bacterial infection). The probability of failure-free survival at 5 years was 75%. The majority of deaths are due to treatment-related complications. Therapy regimens for very late relapse HL are warranted to minimize complications.

Details

Language :
English
ISSN :
16879104
Database :
OpenAIRE
Journal :
Advances in Hematology
Accession number :
edsair.doi.dedup.....3c9cd181673ecb06a1cf4a6b3b5a1def
Full Text :
https://doi.org/10.1155/2011/707542