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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas
- Source :
- Advances in Hematology, Vol 2011 (2011), Advances in Hematology
- Publication Year :
- 2011
- Publisher :
- Hindawi Publishing Corporation, 2011.
-
Abstract
- Recurrences of Hodgkin's Lymphoma (HL) 5 years after the initial therapy are rare. The aim of this study is to report a single centre experience of the clinical characteristics, outcome, and toxicity of pts who experienced very late relapses, defined as relapses that occurred 5 or more years after the achievement of first complete remission. Of 532 consecutive pts with classical HL treated at our Institute from 1985 to 1999, 452 pts (85%) achieved a complete remission. Relapse occurred in 151 pts: 135 (29.8%) within 5 years and 16 over 5 years (3.5%, very late relapses). Very late relapses occurred after a median disease-free interval of 7 years (range: 5–18). Salvage treatment induced complete remission in 14 pts (87.5%). At a median of 4 years after therapy for very late relapse, 10 pts (63%) are still alive and free of disease and 6 (37%) died (1 from progressive HL, 1 from cardiac disease, 1 from thromboembolic disease, 1 from HCV reactivation, and 2 from bacterial infection). The probability of failure-free survival at 5 years was 75%. The majority of deaths are due to treatment-related complications. Therapy regimens for very late relapse HL are warranted to minimize complications.
- Subjects :
- medicine.medical_specialty
Pediatrics
Hodgkin s
Article Subject
business.industry
Salvage treatment
Hematology
Disease
medicine.disease
Lymphoma
Internal medicine
Toxicity
Clinical Study
Medicine
Diseases of the blood and blood-forming organs
Thromboembolic disease
In patient
RC633-647.5
business
Late Relapse
Subjects
Details
- Language :
- English
- ISSN :
- 16879104
- Database :
- OpenAIRE
- Journal :
- Advances in Hematology
- Accession number :
- edsair.doi.dedup.....3c9cd181673ecb06a1cf4a6b3b5a1def
- Full Text :
- https://doi.org/10.1155/2011/707542