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Brain tissue plasticity: protein synthesis rates of the human brain

Authors :
Edwin C. M. Mariman
Joey S J Smeets
Freek G. Bouwman
Jim Dings
Govert Hoogland
Will K. W. H. Wodzig
Annemie P. Gijsen
Astrid M. H. Horstman
Olaf E. M. G. Schijns
Joy P B Goessens
Luc J. C. van Loon
Human Physiology and Sports Physiotherapy Research Group
Physiotherapy, Human Physiology and Anatomy
MUMC+: DA CDL Algemeen (9)
Promovendi NTM
Humane Biologie
RS: NUTRIM - R3 - Respiratory & Age-related Health
RS: NUTRIM - R3 - Chronic inflammatory disease and wasting
MUMC+: MA Med Staf Spec Neurochirurgie (9)
RS: MHeNs - R3 - Neuroscience
MUMC+: MA Niet Med Staf Neurochirurgie (9)
RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Ondersteunend personeel NTM
Source :
Brain, 141:1122. Oxford University Press
Publication Year :
2018
Publisher :
Oxford University Press (OUP), 2018.

Abstract

All tissues undergo continuous reconditioning via the complex orchestration of changes in tissue protein synthesis and breakdown rates. Skeletal muscle tissue has been well studied in this regard, and has been shown to turnover at a rate of 1-2% per day in vivo in humans. Few data are available on protein synthesis rates of other tissues. Because of obvious limitations with regard to brain tissue sampling no study has ever measured brain protein synthesis rates in vivo in humans. Here, we applied stable isotope methodology to directly assess protein synthesis rates in neocortex and hippocampus tissue of six patients undergoing temporal lobectomy for drug-resistant temporal lobe epilepsy (Clinical trial registration: NTR5147). Protein synthesis rates of neocortex and hippocampus tissue averaged 0.17 +/- 0.01 and 0.13 +/- 0.01%/h, respectively. Brain tissue protein synthesis rates were 3-4-fold higher than skeletal muscle tissue protein synthesis rates (0.05 +/- 0.01%/h; P

Details

ISSN :
14602156 and 00068950
Volume :
141
Database :
OpenAIRE
Journal :
Brain
Accession number :
edsair.doi.dedup.....3c9994f44c5bf86415fda68cc1025759
Full Text :
https://doi.org/10.1093/brain/awy015