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Brain tissue plasticity: protein synthesis rates of the human brain
- Source :
- Brain, 141:1122. Oxford University Press
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- All tissues undergo continuous reconditioning via the complex orchestration of changes in tissue protein synthesis and breakdown rates. Skeletal muscle tissue has been well studied in this regard, and has been shown to turnover at a rate of 1-2% per day in vivo in humans. Few data are available on protein synthesis rates of other tissues. Because of obvious limitations with regard to brain tissue sampling no study has ever measured brain protein synthesis rates in vivo in humans. Here, we applied stable isotope methodology to directly assess protein synthesis rates in neocortex and hippocampus tissue of six patients undergoing temporal lobectomy for drug-resistant temporal lobe epilepsy (Clinical trial registration: NTR5147). Protein synthesis rates of neocortex and hippocampus tissue averaged 0.17 +/- 0.01 and 0.13 +/- 0.01%/h, respectively. Brain tissue protein synthesis rates were 3-4-fold higher than skeletal muscle tissue protein synthesis rates (0.05 +/- 0.01%/h; P
- Subjects :
- Male
0301 basic medicine
Time Factors
hippocampus
muscle
Hippocampus
Neurosurgical Procedures
0302 clinical medicine
neocortex
Protein biosynthesis
RESISTANCE EXERCISE
IN-VIVO
Carbon Isotopes
Neuronal Plasticity
Neocortex
Chemistry
INFUSION
Brain
Human brain
Middle Aged
medicine.anatomical_structure
Female
Adult
medicine.medical_specialty
Phenylalanine
Clinical Neurology
Cerebral protein metabolism
METABOLISM
Temporal lobe
03 medical and health sciences
In vivo
Internal medicine
medicine
Humans
BASAL
Letters to the Editor
Neuronavigation
KINETICS
Protein turnover
Proteins
Metabolism
RANDOMIZED-TRIAL
030104 developmental biology
Endocrinology
Epilepsy, Temporal Lobe
IMMOBILIZATION
Neurology (clinical)
Stable isotope methodology
030217 neurology & neurosurgery
INGESTION
Subjects
Details
- ISSN :
- 14602156 and 00068950
- Volume :
- 141
- Database :
- OpenAIRE
- Journal :
- Brain
- Accession number :
- edsair.doi.dedup.....3c9994f44c5bf86415fda68cc1025759
- Full Text :
- https://doi.org/10.1093/brain/awy015