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Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children
- Source :
- Viral Immunology. 27:375-382
- Publication Year :
- 2014
- Publisher :
- Mary Ann Liebert Inc, 2014.
-
Abstract
- The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of cell-free virus by antibodies to hemagglutinin and interference of virus release from infected cells by antibodies to neuraminidase, influenza virus-specific antibodies specifically can bind to infected cells and lyse virus-infected cells through the activation of complement or natural killer (NK) cells, via antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent lysis (CDL). We evaluated preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection. Though both preexisting HAI and CDL antibodies were associated with protection against clinical influenza, our data suggested that CDL was not a better correlate than HAI. We found that ADCC antibodies behaved differently from HAI and CDL antibodies. Unlike HAI and CDL antibodies, preexisting ADCC antibodies did not correlate with protection against clinical influenza. In fact, ADCC antibodies were detected more frequently in the clinical influenza group than the subclinical group. In addition, in contrast to HAI and CDL antibodies, HAI and the ADCC antibodies titers did not correlate. We also found that ADCC, but not CDL or HAI antibodies, positively correlated with the ages of the children.
- Subjects :
- Adult
Male
animal structures
Immunology
Hemagglutinin (influenza)
chemical and pharmacologic phenomena
Antibodies, Viral
medicine.disease_cause
Virus
Cohort Studies
Young Adult
Influenza A Virus, H1N1 Subtype
Original Research Articles
Virology
Influenza, Human
Influenza A virus
medicine
Humans
Prospective Studies
Child
Aged
Aged, 80 and over
Antibody-dependent cell-mediated cytotoxicity
Hemagglutination assay
biology
Antibody-Dependent Cell Cytotoxicity
Antibody titer
Infant
virus diseases
Complement System Proteins
Middle Aged
Child, Preschool
biology.protein
Molecular Medicine
Female
Antibody
Neuraminidase
Biomarkers
Subjects
Details
- ISSN :
- 15578976 and 08828245
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Viral Immunology
- Accession number :
- edsair.doi.dedup.....3c8e3d21329c944d689c2ee959df65c1