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LeSCoD: a new clinical scale for the detection of Lewy body disease in neurocognitive disorders
- Source :
- Journal of Neurology. 268:3886-3896
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Dementia with Lewy bodies remains underdiagnosed in clinical practice mainly because of the low sensitivity of existing diagnostic criteria and a strong overlap with Alzheimer’s pathology that can mask the Lewy phenotype. The objective of this study was therefore to develop and validate a new clinical scale designed to detect signs of Lewy body disease, called LeSCoD for Lewy body Screening scale in Cognitive Disorders. 128 patients who fulfilled the clinical criteria of dementia with Lewy bodies (DLB; n = 32), Alzheimer’s disease (AD; n = 77) or both (n = 19) was prospectively enrolled. 18F-DOPA PET imaging and/or CSF biomarkers were available in some patients. LeSCoD scale was systematically administered and the potential correlation with 18F-DOPA PET imaging was evaluated in a subgroup of patients. LeSCoD scale showed robust internal and external validity. We determined a cut-off of 10 above which the sensitivity and specificity for Lewy body disease diagnosis were 86% and 95%, respectively. The LeSCoD scale correlated with striatal dopamine uptake in 18F-DOPA PET. LeSCoD scale is a simple and reliable tool for the evaluation of Lewy body disease in routine clinical practice, with a higher sensitivity and specificity than the existing criteria. It might be an alternative to the use of dopamine-specific imaging.
- Subjects :
- Lewy Body Disease
Oncology
medicine.medical_specialty
Neurology
Disease
Sensitivity and Specificity
External validity
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Humans
030212 general & internal medicine
Neuroradiology
Lewy body
business.industry
Dementia with Lewy bodies
medicine.disease
Positron-Emission Tomography
Lewy Bodies
Neurology (clinical)
business
Lewy body disease
Neurocognitive
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321459 and 03405354
- Volume :
- 268
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi.dedup.....3c83e18ae23ceb1f7a206cd14d46fd96