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Interictal language functions in temporal lobe epilepsy
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 76:808-814
- Publication Year :
- 2005
- Publisher :
- BMJ, 2005.
-
Abstract
- Objective: To evaluate interictal language functions in patients with medically intractable left and right sided mesial temporal lobe epilepsy (TLE). Methods: Spontaneous speech, language comprehension, confrontation naming, repetition, reading, writing, and word fluency were examined in 12 patients with left sided TLE and 11 patients with right sided TLE. Results: Four patients out of 23 displayed language deficits in more than one language domain. Three further patients exhibited isolated language deficits. Linguistic deficits were observed in both left TLE and right TLE. In quantitative analyses left and right TLE only differed in spontaneous speech (p = 0.02); no difference was found in other language functions, laterality quotient of Wada test, or overall IQ. Qualitative error analysis of object naming, however, showed typical errors associated only with left TLE. Patients with linguistic deficits were older at testing compared to patients without linguistic deficits (p = 0.003), whereas other factors including side of TLE, handedness, educational level, age at epilepsy onset, and duration of epilepsy did not differ between groups. Conclusions: Possible explanations for these findings include neuronal cell loss and deafferentiation in cortical areas, and disruption of the basal temporal language area pathways. Our study suggests that some patients with chronic mesial TLE exhibit linguistic deficits when specifically tested, and underlines the need to routinely investigate linguistic functions in TLE.
- Subjects :
- Adult
Male
Paper
medicine.medical_specialty
Time Factors
Hippocampus
Electroencephalography
Audiology
Severity of Illness Index
behavioral disciplines and activities
Functional Laterality
Temporal lobe
Developmental psychology
Epilepsy
medicine
Humans
Ictal
Aged
Brain Diseases
Language Disorders
Language Tests
Sclerosis
medicine.diagnostic_test
Brain
Videotape Recording
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Comprehension
Psychiatry and Mental health
Epilepsy, Temporal Lobe
nervous system
Laterality
Wada test
Female
Surgery
Neurology (clinical)
Psychology
psychological phenomena and processes
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....3c8258eea217cb5016bf6b3d94ed37fc