Back to Search
Start Over
Roles of LIM kinases in central nervous system function and dysfunction
- Source :
- FEBS Letters, FEBS Letters, Wiley, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs.
- Subjects :
- Central Nervous System
[SDV]Life Sciences [q-bio]
Biophysics
macromolecular substances
LIMK1
Biology
Biochemistry
Lim kinase
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
Structural Biology
Genetics
Animals
Humans
Mode of action
Molecular Biology
030304 developmental biology
Neurons
0303 health sciences
Kinase
Lim Kinases
Cell Biology
Cofilin
Cell biology
Synaptic plasticity
Phosphorylation
030217 neurology & neurosurgery
Function (biology)
Subjects
Details
- ISSN :
- 00145793 and 18733468
- Volume :
- 589
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....3c7f8caf8dab0bf79431bfbc95e2f479