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Nonviral Aβ DNA vaccine therapy against Alzheimer’s disease: Long-term effects and safety
- Source :
- Proceedings of the National Academy of Sciences. 103:9619-9624
- Publication Year :
- 2006
- Publisher :
- Proceedings of the National Academy of Sciences, 2006.
-
Abstract
- It was recently demonstrated that amyloid beta (Abeta) peptide vaccination was effective in reducing the Abeta burden in Alzheimer model mice. However, the clinical trial was halted because of the development of meningoencephalitis in some patients. To overcome this problem, anti-Abeta antibody therapy and other types of vaccination are now in trial. In this study, we have developed safe and effective nonviral Abeta DNA vaccines against Alzheimer's disease. We administered these vaccines to model (APP23) mice and evaluated Abeta burden reduction. Prophylactic treatments started before Abeta deposition reduced Abeta burden to 15.5% and 38.5% of that found in untreated mice at 7 and 18 months of age, respectively. Therapeutic treatment started after Abeta deposition reduced Abeta burden to approximately 50% at the age of 18 months. Importantly, this therapy induced neither neuroinflammation nor T cell responses to Abeta peptide in both APP23 and wild-type B6 mice, even after long-term vaccination. Although it is reported that other anti-Abeta therapies have pharmacological and/or technical difficulties, nonviral DNA vaccines are highly secure and easily controllable and are promising for the treatment of Alzheimer's disease.
- Subjects :
- Time Factors
medicine.medical_treatment
T cell
Antibodies
DNA vaccination
Mice
Alzheimer Disease
Vaccines, DNA
Animals
Humans
Medicine
Neuroinflammation
Cell Proliferation
Amyloid beta-Peptides
Multidisciplinary
biology
business.industry
Immunotherapy
Biological Sciences
medicine.disease
Vaccination
Clinical trial
Disease Models, Animal
medicine.anatomical_structure
DNA, Viral
Immunology
biology.protein
Alzheimer's disease
Antibody
business
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....3c7a8b2ccf53544706a3725c83f22aba