Back to Search
Start Over
Simplextones A and B, Unusual Polyketides from the Marine Sponge Plakortis simplex
- Source :
- Organic Letters. 13:3154-3157
- Publication Year :
- 2011
- Publisher :
- American Chemical Society (ACS), 2011.
-
Abstract
- Two novel polyketides, simplextones A (1) and B (2), were isolated from the sponge Plakortis simplex. Their structures were established by spectroscopic methods. The absolute configurations were assigned by modified Mosher's method, X-ray crystallographic analysis, and quantum mechanical calculation of the electronic circular dichroism (ECD) spectrum. Compounds 1 and 2 featured an unprecedented polyketide skeleton via the connection of a single carbon-carbon bond to form a cyclopentane. These compounds also exhibited moderate cytotoxicity.
- Subjects :
- Circular dichroism
Stereochemistry
Molecular Conformation
Antineoplastic Agents
Marine Biology
Crystallography, X-Ray
Biochemistry
Plakortis simplex
Polyketide
chemistry.chemical_compound
Plakortis
Animals
Humans
Physical and Theoretical Chemistry
Cyclopentane
Molecular Structure
biology
Chemistry
Organic Chemistry
HCT116 Cells
biology.organism_classification
Sponge
Female
Macrolides
Drug Screening Assays, Antitumor
HeLa Cells
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....3c755722586181d4bf37f2131584dbba