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Characterizing the Utility and Limitations of Repurposing an Open-Field Optical Imaging Device for Fluorescence-Guided Surgery in Head and Neck Cancer Patients
- Source :
- Journal of Nuclear Medicine, 58(2), 246-251. SOC NUCLEAR MEDICINE INC
- Publication Year :
- 2016
- Publisher :
- Society of Nuclear Medicine, 2016.
-
Abstract
- The purpose of this study was to assess the potential of U.S. Food and Drug Administration-cleared devices designed for indocyanine green-based perfusion imaging to identify cancer-specific bioconjugates with overlapping excitation and emission wavelengths. Recent clinical trials have demonstrated potential for fluorescence guided surgery, but the time and cost of the approval process may impede clinical translation. To expedite this translation, we explored the feasibility of repurposing existing optical imaging devices for fluorescence-guided surgery. Methods: Consenting patients (n = 15) scheduled for curative resection were enrolled in a clinical trial evaluating the safety and specificity of cetuximab-IRDye800 (NCT01987375). Open-field fluorescence imaging was performed preoperatively and during the surgical resection. Fluorescence intensity was quantified using integrated instrument software, and the tumor-to-background ratio characterized fluorescence contrast. Results: In the preoperative clinic, the open-field device demonstrated potential to guide preoperative mapping of tumor borders, optimize the day of surgery, and identify occult lesions. Intraoperatively, the device demonstrated robust potential to guide surgical resections, as all peak tumor-to-background ratios were greater than 2 (range, 2.2-14.1). Postresection wound bed fluorescence was significantly less than preresection tumor fluorescence (P
- Subjects :
- Male
OROPHARYNGEAL CANCER
Fluorescence-lifetime imaging microscopy
Perfusion scanning
030218 nuclear medicine & medical imaging
chemistry.chemical_compound
0302 clinical medicine
Medicine
MARGINS
SPECIFICITY
Repurposing
Margins of Excision
Equipment Design
Middle Aged
Treatment Outcome
Surgery, Computer-Assisted
Oncology
Head and Neck Neoplasms
SURGICAL-TREATMENT
030220 oncology & carcinogenesis
Female
SQUAMOUS-CELL CARCINOMA
NEAR-INFRARED FLUORESCENCE
fluorescence-guided surgery
Adult
medicine.medical_specialty
RESECTION
5-AMINOLEVULINIC ACID
Sensitivity and Specificity
optical imaging
03 medical and health sciences
Optical imaging
CETUXIMAB-IRDYE800
Equipment Reuse
Humans
Tomography, Optical
XENOGRAFTS
Radiology, Nuclear Medicine and imaging
Aged
business.industry
Head and neck cancer
Reproducibility of Results
Cancer
medicine.disease
Surgery
Equipment Failure Analysis
Clinical trial
Microscopy, Fluorescence
chemistry
head and neck cancer
business
Indocyanine green
Subjects
Details
- ISSN :
- 2159662X and 01615505
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....3c6b4fdde841bbf6c7e58b5a24096b26