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Separability of calcium slow waves and functional connectivity during wake, sleep, and anesthesia
- Source :
- Neurophotonics
- Publication Year :
- 2019
-
Abstract
- Modulation of brain state, e.g., by anesthesia, alters the correlation structure of spontaneous activity, especially in the delta band. This effect has largely been attributed to the ∼1 Hz slow oscillation that is characteristic of anesthesia and nonrapid eye movement (NREM) sleep. However, the effect of the slow oscillation on correlation structures and the spectral content of spontaneous activity across brain states (including NREM) has not been comprehensively examined. Further, discrepancies between activity dynamics observed with hemoglobin versus calcium (GCaMP6) imaging have not been reconciled. Lastly, whether the slow oscillation replaces functional connectivity (FC) patterns typical of the alert state, or superimposes on them, remains unclear. Here, we use wide-field calcium imaging to study spontaneous cortical activity in awake, anesthetized, and naturally sleeping mice. We find modest brain state-dependent changes in infraslow correlations but larger changes in GCaMP6 delta correlations. Principal component analysis of GCaMP6 sleep/anesthesia data in the delta band revealed that the slow oscillation is largely confined to the first three components. Removal of these components revealed a correlation structure strikingly similar to that observed during wake. These results indicate that, during NREM sleep/anesthesia, the slow oscillation superimposes onto a canonical FC architecture.
- Subjects :
- Paper
Neuroscience (miscellaneous)
chemistry.chemical_element
Electroencephalography
Calcium
01 natural sciences
Brain mapping
Non-rapid eye movement sleep
010309 optics
03 medical and health sciences
0302 clinical medicine
Calcium imaging
0103 physical sciences
medicine
Oscillation (cell signaling)
Radiology, Nuclear Medicine and imaging
sleep
calcium
Radiological and Ultrasound Technology
medicine.diagnostic_test
Chemistry
functional connectivity
Eye movement
hemoglobin
Sleep in non-human animals
Research Papers
Anesthesia
slow oscillation
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2329423X
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neurophotonics
- Accession number :
- edsair.doi.dedup.....3c513865b2a29610cd2ef93a3973d504