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Dementia Predictors in Parkinson Disease: A Validation Study
- Source :
- Journal of Parkinson's disease. 7(1)
- Publication Year :
- 2016
-
Abstract
- In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Validation study
Parkinson's disease
Disease
REM Sleep Behavior Disorder
REM sleep behavior disorder
03 medical and health sciences
Cellular and Molecular Neuroscience
Orthostatic vital signs
Hypotension, Orthostatic
0302 clinical medicine
Internal medicine
mental disorders
medicine
Dementia
Humans
Cognitive Dysfunction
Prospective cohort study
Aged
Parkinson Disease
Middle Aged
medicine.disease
Prognosis
030104 developmental biology
Physical therapy
Disease Progression
Female
Neurology (clinical)
Psychology
Validation cohort
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1877718X
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Parkinson's disease
- Accession number :
- edsair.doi.dedup.....3c429b235820bb5dbf72a3baa8d95d46