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Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity
- Source :
- Diabetesmetabolism. 43(3)
- Publication Year :
- 2016
-
Abstract
- Aims Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. Methods Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (p AT O 2 ) in 16 men with OSAS before and after 4 months of continuous positive airway pressure therapy (CPAP) and in BMI-matched controls. Oxygenation was simultaneously monitored in arterial blood by pulse oximetry (SaO 2 ); mixed blood in AT microcirculation by reflectance spectroscopy (S AT O 2 ) along with blood flow. Markers of hypoxia, adipo- and angiogenesis, inflammation and fibrosis were analysed in AT and serum. Results OSAS subjects were more insulin resistant. Despite lower arterial SaO 2 (95.4±1.3% vs. 97.1±1.6%, P =0.013) in subjects with OSAS, there was no difference in the oxygen content of AT microcirculation (61.6±18.4 vs. 72.2±7.0%, P =0.07) or p AT O 2 (49.2±7.5 vs. 50.4±14.7mmHg, P =0.83) between groups. Resting AT blood flow was higher in OSAS compared to controls (108.5±22.7 vs. 78.9±24.9au, P P =0.049) and fibrosis (COL3A1 P =0.02), a trend of higher HIF1A expression ( P =0.06) and reduced adipogenesis (PPARG P =0.006). After CPAP, only expression of the lipid deposition marker LPL increased (30%, P =0.047). Conclusions Adipose tissue of awake OSAS subjects appears no more hypoxic than adipose tissue of BMI-matched controls despite daytime hypoxaemia. Increased adipose tissue blood flow may be explained by an increased inflammatory response. We observe features of adipose dysfunction in subjects with OSAS, which attribute to increased cardiometabolic risk associated with this condition.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Adipose tissue
030209 endocrinology & metabolism
Biology
Microcirculation
03 medical and health sciences
0302 clinical medicine
Endocrinology
Fibrosis
Internal medicine
Internal Medicine
medicine
Humans
Obesity
Hypoxia
Aged
Sleep Apnea, Obstructive
Adiponectin
Leptin
General Medicine
Hypoxia (medical)
Middle Aged
medicine.disease
Obstructive sleep apnea
Oxygen
030104 developmental biology
Adipose Tissue
Case-Control Studies
Arterial blood
medicine.symptom
Insulin Resistance
Subjects
Details
- ISSN :
- 18781780
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diabetesmetabolism
- Accession number :
- edsair.doi.dedup.....3c354f1b6b0c3cf3c07df9f2fc92bf39