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Schizophrenia: forty years of the dopaminergic hypothesis from the medicinal chemistry point of view
- Source :
- Química Nova v.27 n.3 2004, Química Nova, Sociedade Brasileira de Química (SBQ), instacron:SBQ, Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS, Química Nova, Vol 27, Iss 3, Pp 447-455 (2004), Química Nova, Volume: 27, Issue: 3, Pages: 447-455, Published: JUN 2004
- Publication Year :
- 2004
- Publisher :
- Sociedade Brasileira de Química, 2004.
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Abstract
- Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.
Details
- Language :
- Portuguese
- Database :
- OpenAIRE
- Journal :
- Química Nova v.27 n.3 2004, Química Nova, Sociedade Brasileira de Química (SBQ), instacron:SBQ, Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS, Química Nova, Vol 27, Iss 3, Pp 447-455 (2004), Química Nova, Volume: 27, Issue: 3, Pages: 447-455, Published: JUN 2004
- Accession number :
- edsair.doi.dedup.....3c1c3535109caeff1580155bc90fe1a0