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Acute effects of nifedipine, diltiazem and their combinationin patients with chronic stable angina: a double-blind, randomized, cross-over, placebo-controlled study
- Publication Year :
- 1993
-
Abstract
- We evaluated the acute therapeutic effects of the oral administration of nifedipine (10 mg) and diltiazem (120 mg) alone and in combination in 16 patients with effort angina. The 16 patients (13 men and three women; mean age 59 +/- 7 years) performed a symptom-limited bicycle exercise stress test 3 h after placebo or active substance administration. Maximal work load, exercise duration and time to 1 mm ST segment depression were significantly increased and ST depression at peak exercise was significantly decreased by the combination of drugs. Nifedipine and diltiazem alone similarly improved exercise duration as markedly as their combination. One patient stopped the test after all three treatments for angina associated with ST depression2 mm. The combination of drugs yielded the best symptomatic effect: only four patients complained of angina in comparison to eight and seven patients after diltiazem and nifedipine, respectively. Nifedipine and diltiazem are effective and safe antianginal drugs. Some patients respond better to one drug than to the other. Patients who remain symptomatic in spite of maximal doses of a single drug may derive some benefit from combination therapy.
- Subjects :
- Male
Combination therapy
Nifedipine
Blood Pressure
Placebo
Angina Pectoris
Coronary artery disease
Angina
Diltiazem
Double-Blind Method
Heart Rate
medicine
Humans
Aged
ST depression
Exercise Tolerance
business.industry
Therapeutic effect
Middle Aged
medicine.disease
Treatment Outcome
Anesthesia
Chronic Disease
Drug Therapy, Combination
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3c0ef20b699e720498be7b87f6e84239