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Lipiduria--with special relevance to Fabry disease
- Source :
- Clinical chemistry and laboratory medicine. 53
- Publication Year :
- 2015
-
Abstract
- Examination of the urine under the microscope using polarised light is invaluable for detecting and identifying lipid particles. Attention to the shape of these Maltese cross bearing bodies can distinguish conventional fat particles from Fabry bodies with great sensitivity and specificity across a wide phenotypic spectrum. This could be a cheap and rapid tool for screening subjects suspected of having Fabry disease for renal involvement. It remains to be seen whether there is value in integrating polarised light into automated urine microscopy machines, but potentially this could greatly help the pathologist or nephrologist in identifying unusual urinary particles, and broaden the capacity for larger scale screening.
- Subjects :
- Pathology
medicine.medical_specialty
Microscopy
Urinalysis
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Clinical Biochemistry
General Medicine
Polarised light
medicine.disease
Kidney
Fabry disease
Lipids
Sensitivity and Specificity
Urine microscopy
Wide phenotypic spectrum
Medicine
Fabry Disease
Humans
Lipiduria
business
Subjects
Details
- ISSN :
- 14374331
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Clinical chemistry and laboratory medicine
- Accession number :
- edsair.doi.dedup.....3c0e0d632c08151e67e1d30e2af834c9