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Determinants of nonadherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Rwanda
- Source :
- Journal of acquired immune deficiency syndromes (1999). 50(2)
- Publication Year :
- 2009
-
Abstract
- Not the final published version<br />Objectives: To describe experiences, and identify factors associated with nonadherence to a single-dose nevirapine (SD-NVP) regimen for the prevention of mother-to-child transmission (PMTCT) of HIV in Rwanda. Methods: In April to May 2006, using a case-control design at 12 PMTCT sites, we interviewed HIV-infected women who did not adhere (n = 111) and who adhered (n = 125) to the PMTCT prophylaxis regimen. Nonadherence was defined as mother and/or infant not ingesting SD-NVP at the recommended time or not at all and adherence as mother-infant pairs who ingested it as recommended. Results: Only 61% of nonadherent women had received SD-NVP during pregnancy or delivery. Among nonadherent women who received SD-NVP, 80% ingested it at the recommended time, representing 49% of all nonadherent women. Only 7% of their newborns ingested SD-NVP. Multivariate logistic regression showed that unmarried women, less educated women, women who made 2 or less antenatal care visits, and those offered HIV testing after their first antenatal care visit were more likely to be nonadherent to PMTCT prophylaxis. Not disclosing one's HIV status to someone aside from a partner was also associated with nonadherence in mother-infant pairs. Conclusions: Sociodemographic factors, health services delivery factors, and a lack of communication and social support contributed to nonadherence to PMTCT prophylaxis in Rwanda.
- Subjects :
- Adult
medicine.medical_specialty
Nevirapine
Single dose
Anti-HIV Agents
Population
HIV Infections
Viral diseases
Disease transmission, vertical
Women in development
Interviews as Topic
Social support
Acquired immunodeficiency syndrome (AIDS)
immune system diseases
Pregnancy
medicine
Humans
Africa, Central
Pharmacology (medical)
Pregnancy Complications, Infectious
education
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Determinants
education.field_of_study
business.industry
Transmission prevention
Infant, Newborn
Rwanda
HIV
virus diseases
medicine.disease
Infectious Disease Transmission, Vertical
Mother-to-child
AIDS
Regimen
Infectious Diseases
Family medicine
Case-Control Studies
Immunology
Chemoprophylaxis
HIV-1
Patient Compliance
Reverse Transcriptase Inhibitors
Female
business
Compliance
medicine.drug
Subjects
Details
- ISSN :
- 15254135
- Volume :
- 50
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Accession number :
- edsair.doi.dedup.....3c02ac78ab473e30d37a568cd1b49e5a