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Adult brain volume in multiple sclerosis: The impact of paediatric onset
- Source :
- Multiple Sclerosis and Related Disorders. 21:103-107
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Paediatric onset multiple sclerosis (POMS) is associated with reduced brain and deep grey matter volume in comparison with that in healthy controls and individuals with adult onset multiple sclerosis (AOMS). The aim of our study was to evaluate the impact of POMS on adult brain volume with adjustment for other parameters, such as disease duration.We recruited 20 POMS and 40 AOMS patients and 20 healthy controls matched for age and sex. All study participants were adults at the time of inclusion in the study. All study subjects underwent brain magnetic resonance imaging (MRI) to evaluate whole brain, white matter, grey matter, cortical, and deep grey matter volumes. Clinical features, such as the Expanded Disability Status Scale (EDSS) score and disease duration, were also assessed.Brain (p = 0.01), grey matter (p = 0.01), and deep grey matter volume (p = 0.03) was significantly lower in POMS patients than in AOMS patients, while no differences were detected in the volume of white matter or cortical grey matter. A multiple linear regression analysis showed a relationship between brain volume (dependent variable) and the independent variables age (p 0.000) and paediatric onset (p 0.001), while other independent variables, including disease duration, sex, and disability, were not significantly different among groups. There were significant differences in thalamic volume among POMS and AOMS patients and healthy controls.Our data support the previous findings that POMS patients have reduced brain and deep grey matter volume, particularly thalamic volume, compared with sex- and age-matched AOMS patients and healthy controls. These findings appear to be independent of disease duration and other clinical features.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Multiple Sclerosis
Grey matter
Functional Laterality
White matter
Disability Evaluation
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
Age of Onset
Gray Matter
Young adult
Expanded Disability Status Scale
medicine.diagnostic_test
business.industry
Multiple sclerosis
Brain
Magnetic resonance imaging
Organ Size
General Medicine
medicine.disease
Magnetic Resonance Imaging
White Matter
Cross-Sectional Studies
030104 developmental biology
medicine.anatomical_structure
Neurology
Multivariate Analysis
Brain size
Linear Models
Female
Neurology (clinical)
Age of onset
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22110348
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis and Related Disorders
- Accession number :
- edsair.doi.dedup.....3bfd4bdc757aa9d06ba55742a78b1396