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Subacute fatal aluminum encephalopathy after reconstructive otoneurosurgery: A case report
- Source :
- Human Pathology. 32:1136-1140
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- We report a 52-year-old woman who underwent otoneurosurgery to resect acoustic neurinoma. Bone reconstruction was performed with an aluminium (Al)-containing cement. Six weeks later the patient suffered from loss of consciousness, myoclonic jerks, and persistent grand mal seizures, clinical symptoms that resembled those of lethal dialysis encephalopathy of the 1960s and 1970s. She died 6 months later because of septic complications. Light- and electron-microscopic investigation of the central nervous system (CNS) showed pathognomonic Al-containing intracytoplasmic argyrophilic inclusions in choroid plexus epithelia, neurons, and cortical glia. These changes are characteristics of dialysis-associated encephalopathy (DAE), induced nowadays by long-term ingestion of Al-containing drugs (and with benign clinical courses). Atomic absorption spectrometry showed an increase of mean bulk Al concentration of the cortex and subcortex up to 9.3 microg/g (normal range
- Subjects :
- Pathology
medicine.medical_specialty
Encephalopathy
Central nervous system
Biocompatible Materials
Dialysis Encephalopathy
Pathology and Forensic Medicine
Central nervous system disease
Fatal Outcome
Postoperative Complications
Cerebrospinal fluid
Seizures
Parenchyma
medicine
Humans
Brain Chemistry
Brain Diseases
business.industry
Bone Cements
Neurotoxicity
Brain
Middle Aged
medicine.disease
medicine.anatomical_structure
Glass Ionomer Cements
Ear, Inner
Aluminum Silicates
Female
Choroid plexus
business
Aluminum
Subjects
Details
- ISSN :
- 00468177
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Human Pathology
- Accession number :
- edsair.doi.dedup.....3bf837d27ebf5ef30a96c3d7fc2f0acd