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Cellular Communication in Bone Homeostasis and the Related Anti-osteoporotic Drug Development
- Source :
- Current Medicinal Chemistry. 27:1151-1169
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Background:Intercellular crosstalk among osteoblast, osteoclast, osteocyte and chondrocyte is involved in the precise control of bone homeostasis. Disruption of this cellular and molecular signaling would lead to metabolic bone diseases such as osteoporosis. Currently a number of anti-osteoporosis interventions are restricted by side effects, complications and long-term intolerance. This review aims to summarize the bone cellular communication involved in bone remodeling and its usage to develop new drugs for osteoporosis.Methods:We searched PubMed for publications from 1 January 1980 to 1 January 2018 to identify relevant and latest literatures, evaluation and prospect of osteoporosis medication were summarized. Detailed search terms were ‘osteoporosis’, ‘osteocyte’, ‘osteoblast’, ‘osteoclast’, ‘bone remodeling’, ‘chondrocyte’, ‘osteoporosis treatment’, ‘osteoporosis therapy’, ‘bisphosphonates’, ‘denosumab’, ‘Selective Estrogen Receptor Modulator (SERM)’, ‘PTH’, ‘romosozumab’, ‘dkk-1 antagonist’, ‘strontium ranelate’.Results:A total of 170 papers were included in the review. About 80 papers described bone cell interactions involved in bone remodeling. The remaining papers were focused on the novel advanced and new horizons in osteoporosis therapies.Conclusion:There exists a complex signal network among bone cells involved in bone remodeling. The disorder of cell-cell communications may be the underlying mechanism of osteoporosis. Current anti-osteoporosis therapies are effective but accompanied by certain drawbacks simultaneously. Restoring the abnormal signal network and individualized therapy are critical for ideal drug development.
- Subjects :
- 0301 basic medicine
Osteoporosis
Romosozumab
030209 endocrinology & metabolism
Cell Communication
Bioinformatics
Biochemistry
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Drug Development
Strontium ranelate
Osteoclast
Drug Discovery
Bone cell
medicine
Homeostasis
Humans
Pharmacology
Diphosphonates
business.industry
Organic Chemistry
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Denosumab
Osteocyte
Molecular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 09298673
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Current Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....3bea22ed6dae5af714e2987ec77e981a