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Annotated draft genome sequences of three species ofCryptosporidium:Cryptosporidium meleagridisisolate UKMEL1,C. baileyiisolate TAMU-09Q1 andC. hominisisolates TU502_2012 and UKH1
- Source :
- Pathogens and Disease
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Human cryptosporidiosis is caused primarily by Cryptosporidium hominis, C. parvum and C. meleagridis. To accelerate research on parasites in the genus Cryptosporidium, we generated annotated, draft genome sequences of human C. hominis isolates TU502_2012 and UKH1, C. meleagridis UKMEL1, also isolated from a human patient, and the avian parasite C. baileyi TAMU-09Q1. The annotation of the genome sequences relied in part on RNAseq data generated from the oocyst stage of both C. hominis and C. baileyi. The genome assembly of C. hominis is significantly more complete and less fragmented than that available previously, which enabled the generation of a much-improved gene set for this species, with an increase in average gene length of 500 bp relative to the protein-encoding genes in the 2004 C. hominis annotation. Our results reveal that the genomes of C. hominis and C. parvum are very similar in both gene density and average gene length. These data should prove a valuable resource for the Cryptosporidium research community.<br />The release of the draft genome sequence, and corresponding annotation, of Cryptosporidium baileyi, C. hominis isolates TU502_2012 and UKH1, and C. meleagridis, will accelerate research on Cryptosporidium parasites.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Short Communication
animal diseases
030231 tropical medicine
Cryptosporidium
Sequence assembly
Biology
Genome
03 medical and health sciences
0302 clinical medicine
Gene density
parasitic diseases
Humans
Immunology and Allergy
Parasite hosting
Gene
C. hominis TU502_2012
Cryptosporidium baileyi
Genetics
General Immunology and Microbiology
Cryptosporidium meleagridis
Gene Expression Profiling
Computational Biology
High-Throughput Nucleotide Sequencing
Molecular Sequence Annotation
Genomics
General Medicine
biology.organism_classification
Virology
030104 developmental biology
Infectious Diseases
annotation
genome assembly
Transcriptome
Genome, Protozoan
Cryptosporidium hominis
Subjects
Details
- ISSN :
- 2049632X
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Pathogens and Disease
- Accession number :
- edsair.doi.dedup.....3be554b2b92f905df11ad2c2bf98f2ca