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High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice
- Source :
- Università di Pisa-IRIS
- Publication Year :
- 2008
-
Abstract
- Purpose. Several studies have suggested that KRAS somatic mutations may predict resistance to cetuximab- and panitumumab-based treatments in metastatic colorectal cancer (CRC) patients. Nevertheless, most experiences were conducted on samples from primaries. The aim of this study was to evaluate the grade of concordance in terms of KRAS status between primaries and related metastases. Patients and Methods. We analyzed KRAS codon 12 and 13 mutations from formalin-fixed sections of 107 CRC primaries and related metastases. Eight pairs were excluded from the analysis because of the low amount of tumor tissue in the available samples. The main characteristics were: 50 men, 49 women; median age at diagnosis, 71 years (range, 41–84). The metastatic sites analyzed were the liver in 80 patients (80.8%), lung in seven patients (7.1%), and other sites in 12 patients (12.1%). Results. A KRAS mutation was found in 38 (38.4%) primary tumors and in 36 (36.4%) related metastases. The rate of concordance was 96.0% (95% confidence interval, 90.0%–98.9%). Discordance was observed in only four (4%) patients. Conclusions. Our results indicate that the detection of KRAS mutations in either primary or metastatic tumors from patients with CRC is concordant and this assessment could be used to predict response to targeted therapies such as cetuximab and panitumumab. Learning Objectives After completing this course, the reader should be able to: Describe the importance of KRAS mutations in CRC patients.Explain the relevance to cancer treatment of concordance of KRAS status between primary tumors and metastases in CRC patients.Discuss the impact of KRAS mutations as a predictive/prognostic factor in CRC patients. CME This article is available for continuing medical education credit at http://CME.TheOncologist.com
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
Concordance
medicine.disease_cause
Proto-Oncogene Proteins p21(ras)
Proto-Oncogene Proteins
Internal medicine
medicine
Humans
Panitumumab
Neoplasm Metastasis
neoplasms
Aged
Retrospective Studies
Aged, 80 and over
Cetuximab
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
digestive system diseases
Confidence interval
ErbB Receptors
Clinical Practice
Genes, ras
Mutation
ras Proteins
Female
KRAS
KRAS,colorectal tumors
Colorectal Neoplasms
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Università di Pisa-IRIS
- Accession number :
- edsair.doi.dedup.....3bd5e7842f3493483883025602432b26