Back to Search
Start Over
Three-dimensional analysis of injury conditions of single muscle fibers in small animals using phase-contrast X-ray imaging
- Source :
- Microscopy research and technique. 84(1)
- Publication Year :
- 2020
-
Abstract
- Muscle damage can reduces the biological functions and lead to ultimately a disease state. For the reason, it is important to accurately check the state of an injury such as atrophy, and it is required to identify the state of fibers constituting the muscle. This study describes a novel method of analyzing single muscle fibers with injury conditions in three-dimensions. The muscle fibers of the mice were visualized using phase-contrast X-ray projection the microstructure. In additions, it was possible to confirm the status by quantitatively analyzing the injury severity of muscle fibers. Significantly, the muscle conditions of multiple individuals were individually determined. This study could contributes to areas where it is very important to identify microdetailed and quantitative changes of state, such as new drug development.
- Subjects :
- Three dimensional analysis
Histology
Chemistry
Phase-contrast X-ray imaging
X-Rays
Muscle Fibers, Skeletal
030206 dentistry
02 engineering and technology
Muscle damage
021001 nanoscience & nanotechnology
medicine.disease
Radiography
03 medical and health sciences
Medical Laboratory Technology
Mice
0302 clinical medicine
Atrophy
Imaging, Three-Dimensional
Single muscle
medicine
Animals
Anatomy
0210 nano-technology
Instrumentation
Biomedical engineering
Subjects
Details
- ISSN :
- 10970029
- Volume :
- 84
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Microscopy research and technique
- Accession number :
- edsair.doi.dedup.....3bcf6c56218c8b1d756f013f218eb0b7