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Synthesis of methylcellulose/cellulose nano-crystals nanocomposites: Material properties and study of sustained release of ketorolac tromethamine
- Source :
- Carbohydrate Polymers. 188:168-180
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Non-toxic nanocomposites based bio-films obtained from methylcellulose (MC) can reduce environmental problems associated with synthetic polymers. A new facile route for the isolation of cellulose nano-crystals (CNC) from jute waste is successfully utilized here. The fabrication of CNC reinforced MC nanocomposites by film casting technique and the studies of the effect of CNC on the properties of the MC based nanocomposites have been reported. The synthesized nanocomposites have shown improved UV resistance, mechanical, barrier, and thermal properties. FTIR results established the physicochemical compatibility between the drug, MC and CNC in nanocomposites. In vitro permeation studies performed by using Franz diffusion cell revealed diffusion mediated sustained drug release from the devices due to the presence of interaction between MC and CNC through H-bonding, electrostatic interaction between the hydrophilic polymer/CNC chains with the drug and the formation of tortuous path. The nanocomposites can be used for edible packaging and transdermal drug delivery.
- Subjects :
- Materials science
Fabrication
Polymers and Plastics
Diffusion
02 engineering and technology
Methylcellulose
010402 general chemistry
01 natural sciences
Ketorolac Tromethamine
Nanocomposites
chemistry.chemical_compound
Spectroscopy, Fourier Transform Infrared
Materials Chemistry
Cellulose
Fourier transform infrared spectroscopy
Transdermal
chemistry.chemical_classification
Nanocomposite
Organic Chemistry
Polymer
021001 nanoscience & nanotechnology
Casting
0104 chemical sciences
chemistry
Chemical engineering
Nanoparticles
0210 nano-technology
Subjects
Details
- ISSN :
- 01448617
- Volume :
- 188
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Polymers
- Accession number :
- edsair.doi.dedup.....3bc8ed363d0645d87d76d69cf50647c5