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The prognostic role of preoperative systemic immune-inflammation index and albumin/globulin ratio in patients with newly diagnosed high-grade glioma
- Source :
- Clinical Neurology and Neurosurgery. 184:105397
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Objective Preoperative systemic immune-inflammation index (SII) and the albumin/globulin ratio (AGR) have been used as prognostic markers in many malignancies. This study was conducted to evaluate the clinical significance of the preoperative SII and AGR in high-grade glioma (HGG) patients. Patients and methods A total of 169 patients with newly diagnosed HGG were enrolled in the current study. Overall survival (OS) of these patients was estimated by Kaplan-Meier analyses. Univariate and multivariate Cox regression analyses were performed to examine the relationships between OS and prognostic variables in patients with HGG. Results The cut-off values for SII and AGR were 324.38 × 109/L and 1.35, respectively. An inverse correlation was observed between SII and AGR. The Kaplan-Meier survival analyses demonstrated that high SII and low AGR were associated with poor OS of patients with HGG (P = 0.002 and P = 0.012, respectively). Multivariate analyses revealed that both SII (HR 1.641, 95% CI: 1.071–2.515; P = 0.023) and AGR (HR 0.566, 95% CI: 0.335-0.956; P = 0.033) were independent predictive indicators of OS of HGG patients. Conclusions In conclusion, this study demonstrated that high SII and low AGR values may serve as promising prognostic markers to identify HGG patients with poor prognosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Prognostic variable
Multivariate analysis
Globulin
Newly diagnosed
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Glioma
Preoperative Care
medicine
Humans
Clinical significance
In patient
Serum Albumin
Aged
Retrospective Studies
Aged, 80 and over
biology
Brain Neoplasms
business.industry
Proportional hazards model
General Medicine
Middle Aged
biochemical phenomena, metabolism, and nutrition
Prognosis
medicine.disease
Systemic Inflammatory Response Syndrome
030220 oncology & carcinogenesis
biology.protein
bacteria
Female
Serum Globulins
Surgery
Neurology (clinical)
Neoplasm Grading
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03038467
- Volume :
- 184
- Database :
- OpenAIRE
- Journal :
- Clinical Neurology and Neurosurgery
- Accession number :
- edsair.doi.dedup.....3bc567964c945e3cf936f6e7ae6034ac