Structural Characterization of Self-Assembled Monolayers of Neoglycoconjugates Using Atomic Force Microscopy

3 páginas, 5 figuras.
Thiolated self-assembled monolayers of carbohydrates may serve as useful polyvalent tools to mimic the organized presentation of such molecules at the cell surface. SAMs presenting the disaccharide maltose as a neoglycoconjugate were produced, and the structure was studied by high resolution atomic force microscopy. The molecules form highly ordered structures on a gold (111) surface, with lattice parameters determined by the linker moiety rather than the headgroup.
This work was supported by the Spanish Ministerio de Educación y Ciencia (Acción Integrada HF2002-0121 and Project No. BQU02-03734) and the French Ministère des Affaires Etrangères (Programme d'Actions Intégrées PICASSO). P.E. thanks the MEC for financial support.