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The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia
- Source :
- Biological psychiatry. 53(7)
- Publication Year :
- 2003
-
Abstract
- Backgroud The dihydropyrimidinase-related protein (DRP) family, also called the collapsin response mediator protein, is implicated in the developmental process of the nervous system. Dysfunction of DRPs may result in neurodevelopmental abnormalities, which may be a factor in the pathogenesis of schizophrenia. The expression of one member of DRP-2 in humans has been reported to be decreased in the brains of people with schizophrenia. In addition, the DRP-2 gene (Dihydropyrimidinaselike 2; DPYSL2) is located on chromosome 8p21, a region that has been implicated in schizophrenia in genetic linkage studies. Methods We investigated a genetic association between five polymorphisms of the DRP-2 gene and schizophrenia in the Japanese population. Results The *2236 T >C polymorphism in the 3′ untranslated region (3′UTR) exhibited significant differences with respect to the distribution of the genotype and allele in patients compared with control subjects. The frequency of the *2236C allele was significantly higher in control subjects than patients with schizophrenia ( p = .0097) and paranoid-type schizophrenia ( p = .0083). Conclusions Our results suggest that the *2236C allele in the 3′UTR of the DRP-2 gene, or an unknown mutation in linkage disequilibrium with this allele, may reduce the susceptibility to schizophrenia, especially the paranoid subtype.
- Subjects :
- Male
Psychosis
Linkage disequilibrium
Paranoid schizophrenia
Genotype
Biology
Polymerase Chain Reaction
Amidohydrolases
Japan
Genetic linkage
mental disorders
medicine
Humans
Genetic Predisposition to Disease
Allele
Biological Psychiatry
Alleles
Genetic association
Genetics
Schizophrenia, Paranoid
Haplotype
Middle Aged
medicine.disease
Female
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 53
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Biological psychiatry
- Accession number :
- edsair.doi.dedup.....3bb48c03211d47189e96a31643c1f3a6