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COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus
- Source :
- Leukemia, Leukemia, 34(9), 2354-2363. Nature Publishing Group
- Publication Year :
- 2020
-
Abstract
- Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (≥65 years) (odds ratio 3.72 [95% CI 1.79–7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.
- Subjects :
- 0301 basic medicine
Male
Chronic lymphocytic leukaemia
Cancer Research
Chronic Lymphocytic Leukemia, COVID-19
Chronic lymphocytic leukemia
Comorbidity
Severity of Illness Index
chemistry.chemical_compound
0302 clinical medicine
Piperidines
Obinutuzumab
Surveys and Questionnaires
hemic and lymphatic diseases
80 and over
Viral
Chronic
610 Medicine & health
Immunodeficiency
Aged, 80 and over
Leukemia
Mortality rate
Age Factors
Hematology
Middle Aged
Prognosis
Lymphocytic
Oncology
030220 oncology & carcinogenesis
Infectious diseases
Female
Coronavirus Infections
medicine.drug
Bendamustine
medicine.medical_specialty
Pneumonia, Viral
Antineoplastic Agents
Article
NO
03 medical and health sciences
Betacoronavirus
Internal medicine
Severity of illness
medicine
Humans
Chronic Lymphocytic Leukemia
Pandemics
Protein Kinase Inhibitors
Aged
Retrospective Studies
SARS-CoV-2
Venetoclax
business.industry
Adenine
B-Cell
COVID-19
Odds ratio
Pneumonia
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Settore MED/15 - MALATTIE DEL SANGUE
030104 developmental biology
Pyrazoles
Pyrimidines
chemistry
business
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Database :
- OpenAIRE
- Journal :
- Leukemia, Leukemia, 34(9), 2354-2363. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....3babcff36bf58e25e50873c85522c49e