Back to Search Start Over

Multifunctional AuPd-cluster nanotheranostic agents with a cascade self-regulating redox tumor-microenvironment for dual-photodynamic synergized enzyme catalytic therapy

Authors :
Shilei Ren
Rong Dai
Ziliang Zheng
Xuejiao Chen
Shutong Wu
Ruiping Zhang
Zhiguo Gui
Source :
Journal of Materials Chemistry B. 11:109-118
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

Photodynamic therapy (PDT) has emerged as a promising strategy with higher selectivity and spatiotemporal control than conventional therapies. However, deep hypoxia in tumours has hampered the clinical use of PDT. In this study, a novel multifunctional cluster nanotheranostic agent (AuPd-BSA CN) was fabricated to generate a high amount of reactive oxygen species, regardless of oxygen dependence under 660 nm laser irradiation. The structure and properties of the AuPd-BSA CN were characterised using various technologies. The synthesised AuPd-BSA CN with high biocompatibility served as a superior photodynamic agent, showing prominent antitumour properties under laser irradiation. Additionally, the glucose oxidase-like activity of the AuPd-BSA CN synergistically enhanced the therapeutic performance. Notably, the intrinsic characteristics of the AuPd-BSA CN include dual-modal second near-infrared window fluorescence/photoacoustic imaging capabilities for monitoring and tracking the

Details

ISSN :
20507518 and 2050750X
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Materials Chemistry B
Accession number :
edsair.doi.dedup.....3ba6d5cadf54f3eda3a9e3ff088d211e
Full Text :
https://doi.org/10.1039/d2tb02096c