Back to Search Start Over

Consanguinity and increased risk for schizophrenia in Egypt

Authors :
Osama El-Boraie
Mai Elassy
Farha A El-Chennawi
Kodavali V. Chowdari
Lambertus Klei
Warda Fathi
Ahmed Eissa
Hader Mansour
Kareem Kandil
Vishwajit L. Nimgaonkar
Bernie Devlin
Ibtihal Ali
Annie M. Watson
Amal Yassin
Hala El-Boraie
Wafaa El-Bahaei
Joel Wood
Salwa Tobar
Hala Salah
Mohamed Alatrouny
Nahed E. Ibrahim
Hanan Gaafar
Source :
Schizophrenia research. 120(1-3)
Publication Year :
2010

Abstract

Background Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population. Methods A case–control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n = 75; controls, n = 126, and their available parents). The prevalence of consanguinity was estimated from family history data (‘self report’), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n = 63) (‘DNA-based’ rates). Results Self-reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p = 0.000058, 1 d.f.). These differences were confirmed using DNA-based estimates for coefficients of inbreeding (inbreeding coefficients as means ± standard error, cases: 0.058 ± 0.007, controls: 0.022 ± 0.003). Conclusions Consanguinity rates are signifcantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies.

Details

ISSN :
15732509
Volume :
120
Issue :
1-3
Database :
OpenAIRE
Journal :
Schizophrenia research
Accession number :
edsair.doi.dedup.....3ba5bb86ff4ec34c12e98ac63a9db77b