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Consanguinity and increased risk for schizophrenia in Egypt
- Source :
- Schizophrenia research. 120(1-3)
- Publication Year :
- 2010
-
Abstract
- Background Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population. Methods A case–control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n = 75; controls, n = 126, and their available parents). The prevalence of consanguinity was estimated from family history data (‘self report’), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n = 63) (‘DNA-based’ rates). Results Self-reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p = 0.000058, 1 d.f.). These differences were confirmed using DNA-based estimates for coefficients of inbreeding (inbreeding coefficients as means ± standard error, cases: 0.058 ± 0.007, controls: 0.022 ± 0.003). Conclusions Consanguinity rates are signifcantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies.
- Subjects :
- Adult
Male
Bipolar I disorder
Self Disclosure
Population
DNA Mutational Analysis
Consanguinity
Article
Young Adult
medicine
Odds Ratio
Humans
Family history
Risk factor
education
Biological Psychiatry
Genetics
education.field_of_study
Polymorphism, Genetic
business.industry
Case-control study
Odds ratio
medicine.disease
Psychiatry and Mental health
Case-Control Studies
Schizophrenia
Egypt
Female
business
Inbreeding
Demography
Microsatellite Repeats
Subjects
Details
- ISSN :
- 15732509
- Volume :
- 120
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- Schizophrenia research
- Accession number :
- edsair.doi.dedup.....3ba5bb86ff4ec34c12e98ac63a9db77b