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Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease
- Source :
- Pure and Applied Chemistry. 85:1813-1823
- Publication Year :
- 2013
- Publisher :
- Walter de Gruyter GmbH, 2013.
-
Abstract
- Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluorescently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain barrier (BBB) and to stain Aβ‑deposits.
- Subjects :
- fluorescent derivative
Chemistry
Ligand
General Chemical Engineering
General Chemistry
Diagnostic tools
Stain
Fluorescence
Amyloid β peptide
In vitro model
Benzopyran
chemistry.chemical_compound
Binding ability
Biochemistry
BIO/09 - FISIOLOGIA
CHIM/06 - CHIMICA ORGANICA
Aβ-peptide ligand
glycofused compounds
Alzheimer’s disease
Subjects
Details
- ISSN :
- 13653075 and 00334545
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- Pure and Applied Chemistry
- Accession number :
- edsair.doi.dedup.....3ba36e03d79778f364ed44293c27e09f