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Expression of heat shock proteins in the developing rat retina
- Source :
- Neuroscience Letters. 205:215-217
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Expression of three heat shock proteins (HSPs), HSP70, HSP90, and immunoglobulin heavy chain binding protein (Bip) was examined in the developing rat retina using Northern blot analysis. The expression of the inducible form of HSP70 remained uniformly low throughout the perinatal period until P5 and increased rapidly at P7. On the other hand, the constitutive form of HSP70, HSP90, and Bip were expressed constitutively in the rat retina throughout the developmental stage except P3-P5, at which a transient decrease of the expression was observed. The increase of inducible HSP70 mRNA at P7 may correspond to the functional maturation of photoreception in the visual nervous system and may be one of the stress responses to photostimulation. The potential roles of each HSP during development of the rat visual system are discussed.
- Subjects :
- Nervous system
genetic structures
Molecular Sequence Data
Nerve Tissue Proteins
Retina
Photostimulation
GAP-43 Protein
Neurofilament Proteins
Heat shock protein
Gene expression
medicine
Animals
HSP70 Heat-Shock Proteins
HSP90 Heat-Shock Proteins
Northern blot
Rats, Wistar
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
Membrane Glycoproteins
Base Sequence
biology
General Neuroscience
Gene Expression Regulation, Developmental
Blotting, Northern
Hsp90
Molecular biology
Rats
Hsp70
medicine.anatomical_structure
biology.protein
Carrier Proteins
Molecular Chaperones
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 205
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....3b9e66498182aadbbf2656de49f22a00